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. Author manuscript; available in PMC: 2022 Apr 5.
Published in final edited form as: Eur J Med Chem. 2021 Feb 6;215:113272. doi: 10.1016/j.ejmech.2021.113272

Figure 2.

Figure 2.

Dose-response curves and IC50 values of (a) 10 (JH-MR-21), (b) 11 (JH-MR-22), and (c) 20 (JH-MR-23) with MraYAA solubilized in the detergent CHAPS. Each IC50 measurement was made by using the UMP-Glo™ assay. Data are shown as the mean ± standard deviation of three technical replicates. (d) MIC of 20 (JH-MR-23) against S. aureus (strain SA113) is 54 ± 6.8 μg/mL. Representative images of the MIC determination for 20 (JH-MR-23) with growth and sterility controls (4 wells each) as indicated in row B and C (n=8, MIC value is reported as mean ± standard error).