Table 2.
Adjusted Hazard Ratios of BMI Trajectories (Ages 31-80) from Cox Hazard Models in Framingham Heart Study Original Cohort 1948-2010.
| Number of Persons | Number of Deaths | Birth Cohorts and Gender Adjusted | Education Adjusteda | Behavioral Factors Adjustedb | Fully Adjustedc | |
|---|---|---|---|---|---|---|
| HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | HR (95 % CI) | |||
| Body mass index trajectories | ||||||
| Lower level of normald weight | 473 | 404 | 1.48 (1.30, 1.68) | 1.49 (1.31, 1.70) | 1.37 (1.20, 1.56) | 1.40 (1.23, 1.60) |
| Normal weightd stable | 1,087 | 928 | 1.19 (1.07, 1.32) | 1.21 (1.09, 1.34) | 1.17 (1.06, 1.30) | 1.19 (1.07, 1.32) |
| Normal weightd upward | 609 | 499 | 1.00 | 1.00 | 1.00 | 1.00 |
| Overweighte downward | 983 | 849 | 1.37 (1.23, 1.53) | 1.38 (1.24, 1.54) | 1.37 (1.23, 1.53) | 1.38 (1.24, 1.53) |
| Overweighte stable | 956 | 833 | 1.32 (1.18, 1.47) | 1.32 (1.18, 1.46) | 1.34 (1.20, 1.49) | 1.34 (1.20, 1.49) |
| Class I obesef | 382 | 323 | 1.56 (1.35, 1.80) | 1.53 (1.33, 1.77) | 1.58 (1.36, 1.82) | 1.55 (1.34, 1.79) |
| Class II/III obeseg | 86 | 77 | 2.15 (1.72, 2.69) | 2.11 (1.68, 2.64) | 2.18 (1.69, 2.82) | 2.11 (1.63, 2.73) |
| AIC | 56,589.88 | 56,581.22 | 56,446.30 | 56,397.36 | ||
| BIC | 56,665.15 | 56,675.30 | 56,559.20 | 56,516.53 | ||
| Observations | 44,261 | 44,261 | 44,261 | 44,261 | ||
a
Adjusted for birth cohorts, gender, and education
b
Adjusted for birth cohorts, gender, education, and smoking behavior
c
Adjusted for birth cohorts, gender, education, smoking behavior, and disease index
d
Normal weight was defined as having a BMI between 18.5 and 24.9 kg/m2
e
Overweight was defined as having a BMI between 25 and 29.9 kg/m2
f
Class I obesity was defined as having a BMI between 30 and 34.9 kg/m2
g
Class II/III obesity was defined as having a BMI greater than or equal to 35 kg/m2