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(A) Molecular docking model of 14 (cyan) with RIPK2 (PDB:5AR2). Hydrogen bonding interactions (1.8 Å) between the inhibitor and hinge residue M98, as well as the salt-bridge between K47 and E66 of the αC-helix are shown. Also highlighted is the DFG motif. (B) Molecular docking model of 33 (green) with RIPK2 (PDB:5AR2). Hydrogen bonding interaction (3.2 Å) between the inhibitor and S25 is indicated.
