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. Author manuscript; available in PMC: 2022 Apr 5.
Published in final edited form as: Eur J Med Chem. 2021 Feb 3;215:113252. doi: 10.1016/j.ejmech.2021.113252

Scheme 3. Synthesis of 6-phenyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones 15 – 37 and 39-40 *.

Scheme 3.

* Reagents and conditions: (a) Pd/C (10%), H2 (1 atm), CH3OH, rt, overnight (96%); (b) HCO2H, rt or 60 °C, overnight (79-80%); (c) m-CPBA, DCM, rt, 3-5 h (40-93%); (d) A13a, A13b or A13c, NaH, THF:DMF (1:1), 0 °C to rt, 2.5 h (33-95%). Numbering of the phenylpyrido[2,3-d]pyrimidin-7-one ring system present in compounds 15 – 40 is indicated.