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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: J Magn Reson. 2021 Feb 3;325:106927. doi: 10.1016/j.jmr.2021.106927

Figure 2.

Figure 2.

The spectral-spatial pulse used in this work, designed using the spectral spatial RF pulse design package (https://github.com/LarsonLab/Spectral-Spatial-RF-Pulse-Design). The excitation waveform (A) consists of 9 subpulses with a total duration of 6.6 ms and slice thickness of 1 cm. The real RF B1 magnitude shown corresponds to a 90 degree excitation, and is scaled down to achieve lower excitation angles in HP experiments. A 420 Hz passband and 930 Hz stopband allow selective imaging of pyruvate and lactate at 7 T (B). 13C urea at −1680 Hz (arrow) falls within an aliased passband when the MRI center frequency is set to lactate, but can be presaturated when using this pulse for dynamic imaging. Bloch simulation of the transverse magnetization response to this pulse (C) agrees with measurement in a relaxed water phantom (D).