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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: J Magn Reson. 2021 Feb 3;325:106927. doi: 10.1016/j.jmr.2021.106927

Figure 5.

Figure 5.

The spatial fidelity of both chemical shift imaging methods used in this work was evaluated in LDH enzyme phantom experiments. In these experiments only the vials seen on the left side of these images were preloaded with LDH, which catalyzed production of lactate when HP pyruvate was injected simultaneously into both vials. HP signal is plotted over time for a voxel at the center of each vial, showing similar substrate delivery and conversion trends for spectrally selective excitations and multi-excitation CSE imaging with lactate signal confined to the vial containing LDH. Note that due to variations in absolute polarization level and in the rate of imaging agent delivery by manual injection, this experiment is not suitable for quantitative SNR comparison of spectral-spatial and multi-excitation CSE imaging. Dynamic pyruvate (blue) and lactate (orange) images are therefore normalized to their respective maximum intensities.