Table 1.

Key Variables and Data Collection

Concept	Measure	Data Collection Time Points
		24 hours Pre-Study	Study Admission	ICU Days 1–5	ICU Days 6–7	24–72 hours Post-ICU Discharge	1 Month Post-Hospital Discharge	6 Months Post-Hospital Discharge
Delirium
ICU delirium	CAM-ICU 7		•	•	•
Post-ICU delirium	CAM					•	•	•
Provider report of delirium	Documentation of delirium	•	•	•	•	•
Activity/Sleep	Actigraphy		•	•		•	•	•
	SP-PSG		•	•		•	•	•
Iatrogenic, Environmental, and Biobehavioral Factors
Ambient light	Actigraphy		•	•		•	•	•
Pharmacological therapies affecting sleep and/or cognition	Drug type and cumulative sedative dose	•	•	•	•	•	•	•
Disease severity and comorbid conditions	APACHE III			•
	STOP-BANG			•
	SOFA			•	•	•
Demographic characteristics	Age, sex, race/ethnicity		•
Patient-reported Health Status	PROMIS Global Health					•	•	•
Patient-reported Sleep Quality	PROMIS-SD					•	•	•
	PROMIS-SRI					•	•	•
Patient-reported Cognitive Function	PROMIS-CF					•	•	•
	PROMIS-CFA					•	•	•
Cognitive Function	NIH Toolbox Cognition Battery					•	•	•

Note.

CAM-ICU 7: Confusion Assessment Method for the Intensive Care Unit 7.

CAM: Confusion Assessment Method.

SP-PSG: Sleep Profiler polysomnography.

APACHE III: Acute Physiology, Age, and Chronic Health Evaluation III.

STOP-BANG: STOP-BANG Questionnaire.

SOFA: Sequential Organ Failure Assessment.

PROMIS: Patient-Reported Outcomes Measurement Information System.

PROMIS-SD: Sleep Disturbance.

PROMIS-SRI: Sleep Related Impairment.

PROMIS-CF: Cognitive Function.

PROMIS-CFA: Cognitive Function Abilities.

NIH Toolbox: National Institutes of Health Toolbox.