Table 2.

I Can! study measures. All measures are collected at baseline, 3, 6, and 12 months, excepted where noted.

Primary aims
Objective Processing Speed	Oral Symbol Digit Test from the NIH Toolbox Cognition measures [64,65]
Self-reported Cognition	PROMIS Cognitive Function Measure [66]
Secondary Aims
Psychological Mechanisms	PROMIS Anxiety, Depression, Fatigue, and Physical Functioning Measures for Cancer Survivors [67]
DNA methylation age	Aging-associated DNA methylation profiling, including bi-sulfite sequencing and Illumina Mi-Seq [68]
Dose-Response
Physical Activity & Fitness	7-day, waking hours, hip worn ActiGraph GT3X+ [74,75], 3-min step-test [76], 30-s sit-to-stand test [77]
Other relevant measures
Height & weight	Digital scale & stadiometer (height baseline only)
Demographics (baseline only)	Age, education, income, race, and marital status with standard surveys
Clinical	Chart reviews for date of diagnosis, stage at diagnosis, cancer treatments, date of end of active treatment, hormonal therapy, ER, PR, and HER2 status, and current medications. (baseline only)
	Self-report of medical history (baseline and 12 months only)
Memory domain	Hopkins Verbal Learning Test-Revised [79], NIH Toolbox Picture Sequence Memory Test & List Sorting Working Memory Test [65]
Executive Functioning domain	Trail Making Test [80] & NIH Toolbox Dimensional Change Card Sort Test [65]
Attention domain	NIH Toolbox Flanker Inhibitory Control and Attention Test [65] & Conners’ Continuous Performance Test 3 (CPT-3) [81]
Crystalized cognitive ability	National Adult Reading Test [82] (baseline only)
Quality of Life	PROMIS Sleep-related Impairment [83] and General Self-efficacy [84]; Cognitive and Affective Mindfulness Scale-Revised [85]