Skip to main content
. Author manuscript; available in PMC: 2022 Mar 30.
Published in final edited form as: Circulation. 2021 Jan 22;143(13):1302–1316. doi: 10.1161/CIRCULATIONAHA.120.050432

Figure 1. Integrated epigenomic analysis identifies candidate enhancer regions for MYH7 and LMNA.

Figure 1.

MYH7 encodes β-myosin heavy chain (MHC), the major contractile protein in the human left ventricle; mutations in MYH7 are a leading cause of inherited cardiomyopathy. Mutations in LMNA, which encodes lamin A/C also contribute to inherited cardiomyopathies. We intersected enhancer data from multiple sources to identify regulatory regions around these genes. Candidate enhancer regions are shown in yellow. A. The MYH6/7 genes are in near two clusters of candidate enhancers, highlighted in yellow boxes. B. Integrated epigenomic analysis identified three candidate enhancer clusters at the LMNA locus. The labels on the left indicate the data and cell/tissue source (full source listing is found in Table I in the Supplement). pcHi-C, promoter capture Hi-C. LV, left ventricle. IPSC-CMs, IPSC-derived cardiomyocytes.