Fig. 2.

Bone parameters and mechanical properties. a Bone volume significantly decreased with age in both male and female mice (p<0.0001, ES=0.683 and p<0.0001, ES=0.767, respectively). b Cortical porosity increased significantly with age in both male and female mice (p=0.002, ES=0.348 and p=0.003, ES0.319, respectively). c Representative μCT images of female (top – 16Ch, 16Ca, 78Ch, 78Ca) mouse femurs. d Representative μCT images of male (bottom – 16Ch, 16Ca, 78Ch, 78Ca) mouse femurs. e Ultimate force significantly decreased with age in female mice (p=0.001, ES=0.406), but there were no differences in male mice. f Total work was significantly different with age in both male and female mice (p=0.041, ES=0.192 and p=0.005, ES=0.323). Group sizes of 6–8. Data plotted as mean and standard deviation with point plots representing individual animal data. Bars not sharing the same letter are statistically different.