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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Bioorg Chem. 2021 Feb 9;109:104702. doi: 10.1016/j.bioorg.2021.104702

Table 2.

[35S]-GTPγS Functional Assay Results of Compounds 1b, 1c, 6b, and 6c.a

Compounds KOR [35S]-GTPγS binding MOR [35S]-GTPγS binding DOR [35S]-GTPγS binding

EC50 (nM) % Emax of U50,488H EC50 (nM) % Emax of DAMGO EC50 (nM) % Emax of DPDPE
1b 0.34 ± 0.03 98.76 ± 1.52 0.42 ± 0.05 61.29 ± 1.11 15.79 ± 2.96 57.34 ± 2.48
6b 81.88 ± 9.09 99.27 ± 2.79 290.90 ± 41.99 33.62 ± 3.92 2675 ± 689 145.10 ± 12.31
1c (NCP) 0.28 ± 0.03 97.14 ± 1.50 1.82 ± 0.28 58.14 ± 1.48 29.88 ± 3.99 55.68 ± 1.71
6c 92.00 ± 8.47 100.20 ± 2.37 338.43 ± 31.10 26.48 ± 3.73 1850 ± 152 113.90 ± 3.10
a

The values are the mean ± SEM of at least three independent experiments.