Table 2.
Compounds | KOR [35S]-GTPγS binding | MOR [35S]-GTPγS binding | DOR [35S]-GTPγS binding | |||
---|---|---|---|---|---|---|
EC50 (nM) | % Emax of U50,488H | EC50 (nM) | % Emax of DAMGO | EC50 (nM) | % Emax of DPDPE | |
1b | 0.34 ± 0.03 | 98.76 ± 1.52 | 0.42 ± 0.05 | 61.29 ± 1.11 | 15.79 ± 2.96 | 57.34 ± 2.48 |
6b | 81.88 ± 9.09 | 99.27 ± 2.79 | 290.90 ± 41.99 | 33.62 ± 3.92 | 2675 ± 689 | 145.10 ± 12.31 |
1c (NCP) | 0.28 ± 0.03 | 97.14 ± 1.50 | 1.82 ± 0.28 | 58.14 ± 1.48 | 29.88 ± 3.99 | 55.68 ± 1.71 |
6c | 92.00 ± 8.47 | 100.20 ± 2.37 | 338.43 ± 31.10 | 26.48 ± 3.73 | 1850 ± 152 | 113.90 ± 3.10 |
The values are the mean ± SEM of at least three independent experiments.