Table 1.
Slope, β, and significance, p, of the regression terms incorporated in the multiple linear regression given by: MWF ~ β0 + βBMI × BMI + βage × age + βage2 ×age2 + βsex × sex + βethnicity × ethnicity. Sex and ethnicity results are not shown as they exhibited non-significant associations with MWF in all ROIs. All p-values presented are obtained after FDR correction.
| MWF | ||||||
|---|---|---|---|---|---|---|
| BMI | Age | Age2 | ||||
| βBMI (× 103) | pBMI | βage (× 104) | page | βage2 (× 105) | page2 | |
| WB | −1.46 | 0.053 | −7.19 | 0.000 | −2.06 | 0.012 |
| FL | −1.68 | 0.049 | −8.56 | 0.000 | −2.29 | 0.012 |
| OL | −1.37 | 0.099 | −5.73 | 0.000 | −2.29 | 0.019 |
| PL | −1.45 | 0.036 | −6.34 | 0.000 | −2.08 | 0.013 |
| TL | −1.75 | 0.029 | −8.68 | 0.000 | −2.16 | 0.012 |
| CRB | −1.06 | 0.108 | −4.52 | 0.000 | −1.11 | 0.104 |
| BCC | −1.36 | 0.100 | −7.53 | 0.000 | −1.79 | 0.038 |
| GCC | −1.90 | 0.019 | −9.51 | 0.000 | −1.55 | 0.034 |
| SCC | −1.58 | 0.036 | −6.92 | 0.000 | −2.51 | 0.012 |
| IC | −1.53 | 0.053 | −7.17 | 0.000 | −1.74 | 0.026 |
| CP | −0.93 | 0.137 | −3.15 | 0.000 | −0.91 | 0.156 |
| ACR | −2.38 | 0.017 | −10.30 | 0.000 | −1.93 | 0.030 |
| PCR | −3.09 | 0.005 | −11.15 | 0.000 | −2.59 | 0.012 |
| ATR | −2.18 | 0.017 | −8.82 | 0.000 | −1.49 | 0.056 |
| PTR | −1.76 | 0.050 | −9.60 | 0.000 | −2.10 | 0.021 |
| SFOF | −1.90 | 0.036 | −10.42 | 0.000 | −2.30 | 0.012 |
| IFOF | −1.76 | 0.053 | −9.10 | 0.000 | −2.10 | 0.024 |
| SLF | −2.54 | 0.005 | −8.55 | 0.000 | −2.11 | 0.012 |
| ILF | −1.68 | 0.005 | −7.57 | 0.000 | −2.17 | 0.023 |
| Fm | −1.70 | 0.055 | −7.25 | 0.000 | −2.39 | 0.012 |
| FM | −0.50 | 0.508 | −3.81 | 0.001 | −1.65 | 0.044 |
MWF: myelin water fraction, BMI: body mass index, WB: whole brain, FL: frontal lobes, PL: parietal lobes, TL: temporal lobes, OL: occipital lobes, CRB: cerebellum, BCC: body of corpus callosum, GCC: genu of corpus callosum, SCC: splenium of corpus callosum, IC: internal capsules, CP: cerebral peduncle, ACR: anterior corona radiata, PCR: posterior corona radiata, ATR: anterior thalamic radiation, PTR: posterior thalamic radiation, IFOF: inferior fronto-occipital fasciculus, SFOF: superior fronto-occipital fasciculus, ILF: inferior longitudinal fasciculus, SLF: superior longitudinal fasciculus, Fm: forceps minor, FM: forceps major.