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. Author manuscript; available in PMC: 2022 May 28.
Published in final edited form as: Cancer Lett. 2021 Mar 6;506:95–106. doi: 10.1016/j.canlet.2021.03.002

Figure 7. CXCR3 knock out attenuates immune cells recruitment and IFN-γ expression induced by IRF-1 overexpressing in murine HCC tumor.

Figure 7.

A) Tumor image (right) and growth curves (left, mean ± SEM) of murine HCC tumor with negative control (NC) grown in wild type (WT) mice (row 1, blue, n=4) and CXCR3 KO (CXCR3−/−) mice (row 2, green, n=4), as well as tumor overexpressing IRF-1 (IRF-1) grown in WT mice (row 3, red, n=4) and CXCR3−/− mice (row 4, purple, n=4). B-F) Representative images and statistical summary of FACS assay for NK cells (B), NKT cells (C), CD3+ T cells (D), CD8+ T cells (E), and CD4+ T cells (F) number per cubic centimeter of tumor expressing IRF-1 vs. NC subcutaneously grown in WT or CXCR3−/− mice, respectively. G, H) Representative images and statistical summary of FACS assay for IFN-γ+ NK cells (G) and NKT cells (H) number per cubic centimeter of tumor expressing IRF-1 vs. NC subcutaneously grown in WT or CXCR3−/− mice, respectively. Each data point represents one mouse (n=4, each group). The statistical analyses on four different groups are performed by One-way ANOVA. The t test is used to compare between two different groups. Data represent mean ± SD, *p<0.05, **p<0.01.