Table 3.

Cortical properties of right (non-loaded) and left (loaded) tibiae (n=20 per group).

	Non-loaded		Loaded		Non-loaded		Loaded		Temperature	Loading	Treatment	Temperature * Loading	Temperature * Treatment	Loading * Treatment	Temperature * Loading * Treatment
	Control	RAL	Control	RAL	Control	RAL	Control	RAL
Total area (mm2)	1.26 ± 0.07	1.3 ± 0.07	1.43 ± 0.06	1.43 ± 0.05	1.24 ± 0.06	1.32 ± 0.05	1.41 ± 0.05	1.43 ± 0.04	0.6868	<0.0001	0.0043	0.4527	0.2365	<0.0001	0.5296
Marrow Area (mm2)	0.49 ± 0.03	0.49 ± 0.03	0.52 ± 0.05	0.5 ± 0.03	0.5 ± 0.03	0.51 ± 0.04	0.52 ± 0.04	0.52 ± 0.03	0.0780	<0.0001	0.8589	0.3645	0.3602	0.0127	0.9386
Bone Area (mm2)	0.77 ± 0.06	0.81 ± 0.05	0.91 ± 0.03	0.93 ± 0.04	0.75 ± 0.04	0.81 ± 0.03	0.89 ± 0.04	0.91 ± 0.03	0.0254	<0.0001	<0.0001	0.9864	0.3358	0.0057	0.4614
Bone Area Fraction (%)	61.36 ± 1.87	62.37 ± 1.97	63.69 ± 2.15	64.94 ± 1.7	60.02 ± 1.7	61.18 ± 2.25	63.02 ± 1.88	63.89 ± 1.61	0.0022	<0.0001	0.0021	0.4424	0.8679	0.9651	0.6203
Cortical Thickness (mm)	0.24 ± 0.01	0.24 ± 0.01	0.26 ± 0.01	0.27 ± 0.01	0.23 ± 0.01	0.24 ± 0.01	0.26 ± 0.01	0.26 ± 0.01	0.005	<0.0001	<0.0001	0.8663	0.5172	0.1900	0.6031
Imax (mm4)	0.2 ± 0.03	0.22 ± 0.03	0.27 ± 0.03	0.27 ± 0.02	0.18 ± 0.02	0.21 ± 0.01	0.26 ± 0.02	0.26 ± 0.02	0.0034	<0.0001	0.0585	0.7573	0.6017	0.0001	0.3859
Imin (mm4)	0.07 ± 0.01	0.08 ± 0.01	0.1 ± 0.01	0.1 ± 0.01	0.07 ± 0.01	0.08 ± 0.01	0.09 ± 0.01	0.1 ± 0.01	0.5483	<0.0001	0.0007	0.3130	0.1056	0.0355	0.9326
TMD (g/cm3 HA)	1.26 ± 0.03	1.26 ± 0.03	1.24 ± 0.05	1.23 ± 0.05	1.28 ± 0.03	1.28 ± 0.03	1.25 ± 0.02	1.26 ± 0.04	0.0035	<0.0001	0.5888	0.8199	0.6075	0.7421	0.1712