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. 2021 Jan 4;276(35):33220–33232. doi: 10.1074/jbc.M104097200

Figure 2.

Figure 2

Schematic representation of the N-terminalHCoVpp1a/pp1ab region and the proteins tested for proteolytic activity. The numbering of the amino acids is according to Ref.47. The putative nucleophilic cysteine residues of PL1pro and PL2pro are indicated. The positions of the PL1pro p9↓p87 cleavage site (25) and two additional PLpro cleavage sites (this study) are given. The proteins tested for proteolytic activity are depicted on theleft, and the black lines designate these proteins in relation to their positions in pp1a and pp1ab. See “Experimental Procedures” for a description of the generation of each expression construct.