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. 2021 Jan 4;276(35):33220–33232. doi: 10.1074/jbc.M104097200

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© 2001 © 2001 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.

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Proposed scheme for the proteolytic processing of coronavirus replicative polyproteins by the accessory proteases PL1pro and PL2pro. Cleavage sites (P1 and P1′ residues indicated) identified in the pp1a/pp1ab proteins of IBV, MHV, HCoV, and TGEV and the corresponding processing products identified in virus-infected cells are shown. Putative cleavage sites, which are predicted on the basis of the results of the present study, are indicated by ?. Also, the protease domains responsible for specific cleavages are given, with solid lines indicating experimentally characterized cleavages and dotted linesindicating predicted cleavages. The proteolytically inactive IBV PL1pro is marked by a black background color. For other abbreviations see Figs. 1B and 3.