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. 2021 Mar 30;11:7197. doi: 10.1038/s41598-021-85477-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The absence of Myo1g affects the migratory phenotype of activated B lymphocytes. (a) Representative images (40 × objective) of migrating LPS + IL-4 activated WT B cells in a CXCL13 gradient. Myo1g is polarized toward the leading edge (white arrows). (b) Representative images (63 × objective) of activated WT or Myo1g^−/− B lymphocytes migrating on Fibronectin or Poly-l-Lysine coated slides in a CXCL13 gradient 30 min, followed by staining with TRITC-Phalloidin. Scale bars 5 μm. n = 3. (c) Measurement of the number of membrane protrusions, (d) length of protrusions, and (e) elliptical factor of CXCL13-stimulated WT or Myo1g^−/− B lymphocytes migrating on Fibronectin and Poly-l-Lysine coated slides. Data correspond to three independent experiments. Data are presented as mean ± s.d. ****P < 0.0001.