Fig. 1. Cohort level Z-scores for a genome-wide significant SNP that was identified as non-replicable for a Smoking Initiation (SmkInit) phenotype from GSCAN Consortium.
Cross-mark indicates the meta-analysis z-score from a two-sided hypothesis test unadjusted for multiple comparisons. The size of the dot is proportional to the sample size of the cohort. Identified “outlier” summary statistic is marked as orange, which has a disproportionally large Z-score and drives the meta-analysis association results. The purple triangle indicates the MAMBA estimated Z-score, the posterior probability of replicability is 9 × 10−22, very close to 0. Source data are provided as a Source Data file.