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. 2021 Mar 30;12:1964. doi: 10.1038/s41467-021-21226-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Each vertical line represents a SNP analyzed by the MAMBA, where the line extends to a purple cross indicating the fixed-effects p-value. Orange triangles on the same line indicate the MAMBA p-values for the same SNP. Green points are the p-values for randomly pruned markers included in the MAMBA model to ensure that both non-replicable and replicable associations are incorporated. P-values for the MAMBA model were calculated through a bootstrap procedure. All p-values are two-sided and not adjusted for multiple comparisons. Source data are provided as a Source Data file.