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. 2021 Mar 30;11:7159. doi: 10.1038/s41598-021-86200-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of SNPs per gene along chromosome X. (a) Total SNPs per kb of coding sequence per gene. (b) Sex biased variant detection along chromosome X. Bias is calculated as fold change ratio between the mean number of SNPs per individual per gene for males and females. Specifically, this was calculated for each gene as log2((mean male SNPs + 1)/(mean female SNPs + 1)). The ones were added to remove undefined results caused by dividing by the number 0.