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. 2021 Mar 30;12:1965. doi: 10.1038/s41467-021-22284-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Selected merged cell images for three phases of cell cycle. The scale bar is 5 μm. b The changes of the averaged single-cell spot counts of three combinational chromatin modifications. The cell numbers of G1, S, and G2 phases are each 45, 43, and 52 for H3K4me3, and 38, 37, and 50 for H3K27ac. c The spot percentages of three combination sites of single cells.