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. 2021 Mar 30;12:1965. doi: 10.1038/s41467-021-22284-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Selected merged cell images for three breast cell lines. The letter “d” indicates the distance of the spot to nucleus periphery. The scale bar is 5 μm. b Statistical analysis of the distances of spot to the nucleus periphery. The cell numbers are each 52, 44, and 64. c The detection of clinical tissues (No. 1–14) and FNA samples (No. 15–17) with a microfluidic chip. Upper panel, the schematic illustration of the workflow; bottom panel, heat map showing the averaged single-cell spot counts of three combinational chromatin modifications.