TABLE 1.

Correlation analysis between TRiC and genes markers of immune cells in GEPIA.

Description			CD8+ T cell		T cell (general)			B cell		Tfh	M1		M2		TAM
Gene markers			CD8A	CD8B	CD3D	CD3E	CD2	CD19	CD79A	BCL6	NOS2	ROS	ARG1	MRC1	HLA-G	CD80	CD86
TCP1	Tumor	R	–0.039	0.014	–0.092	–0.072	–0.017	–0.088	–0.1	–0.078	0.024	0.12	–0.031	0.019	–0.0011	0.17	0.11
		P	0.19	0.64	*	0.018	0.59	*	**	0.01	0.43	***	0.3	0.52	0.97	***	***
	Normal	R	0.43	0.38	0.17	0.19	0.27	–0.016	0.038	–0.057	0.15	–0.14	0.3	–0.13	–0.035	0.18	0.022
		P	***	***	0.066	0.046	*	0.87	0.69	0.55	0.11	0.14	*	0.16	0.72	0.056	0.82
CCT2	Tumor	R	–0.058	–0.05	–0.1	–0.09	–0.069	–0.082	–0.1	–0.032	–0.025	0.015	–0.019	–0.019	–0.028	0.011	–0.031
		P	0.056	0.1	**	*	0.022	*	**	0.29	0.4	0.63	0.53	0.54	0.35	0.72	0.31
	Normal	R	0.42	0.37	0.21	0.19	0.22	0.022	0.09	–0.17	0.061	–0.12	0.27	–0.23	0.0058	0.22	–0.0071
		P	***	***	0.023	0.041	0.02	0.81	0.34	0.067	0.52	0.21	*	0.016	0.95	0.019	0.94
CCT3	Tumor	R	–0.11	0.056	–0.15	–0.15	–0.11	–0.15	–0.19	–0.074	0.018	–0.0019	0.0033	–0.06	0.043	0.081	–0.04
		P	**	0.064	***	***	**	***	***	0.015	0.56	0.95	0.91	0.048	0.16	*	0.18
	Normal	R	0.45	0.53	0.32	0.3	0.3	0.09	0.18	–0.29	0.072	–0.13	0.27	–0.46	0.15	0.19	–0.17
		P	***	***	**	**	*	0.35	0.061	*	0.45	0.19	*	***	0.11	0.049	0.07
CCT4	Tumor	R	–0.041	0.056	–0.082	–0.084	–0.028	–0.1	–0.12	–0.15	0.054	0.085	–0.037	0.026	0.02	0.15	0.067
		P	0.17	0.064	*	*	0.35	**	***	***	0.075	*	0.22	0.39	0.5	***	0.027
	Normal	R	0.5	0.53	0.26	0.31	0.32	–0.0042	0.095	–0.31	0.051	–0.13	0.3	–0.45	–0.0014	0.067	0.19
		P	***	***	*	*	**	0.96	0.32	***	0.59	0.17	*	***	0.89	0.48	0.043
CCT5	Tumor	R	–0.031	0.036	–0.094	–0.079	–0.031	–0.088	–0.11	–0.041	0.053	0.062	–0.014	–0.014	0.15	0.19	0.095
		P	0.31	0.23	*	*	0.31	*	**	0.18	0.079	0.041	0.64	0.65	***	***	*
	Normal	R	0.27	0.22	0.17	0.17	0.18	0.09	0.11	–0.012	0.0042	0.05	0.12	0.052	0.14	0.29	0.19
		P	*	0.019	0.066	0.081	0.058	0.35	0.25	0.9	0.96	0.6	0.19	0.58	0.15	*	0.043
CCT6A	Tumor	R	–0.033	–0.0098	–0.032	–0.031	–0.012	–0.039	–0.044	–0.063	0.0036	0.0076	–0.0088	–0.012	–0.0018	0.038	0.036
		P	0.28	0.75	0.29	0.3	0.7	0.2	0.15	0.037	0.9	0.8	0.77	0.7	0.95	0.21	0.24
	Normal	R	0.54	0.49	0.37	0.37	0.4	0.11	0.16	–0.36	–0.052	0.05	0.23	–0.28	0.092	0.27	0.096
		P	***	***	***	***	***	0.24	0.086	***	0.58	0.6	0.014	*	0.33	*	0.31
CCT6B	Tumor	R	–0.096	–0.099	–0.14	–0.12	–0.12	0.0011	–0.13	0.12	–0.011	–0.027	–0.01	0.0068	–0.03	–0.079	–0.068
		P	*	*	***	***	***	–0.099	***	***	0.72	0.38	0.73	0.82	0.33	*	0.025
	Normal	R	0.39	0.4	0.17	0.18	0.18	0.021	0.31	–0.22	0.24	–0.18	0.26	–0.41	0.01	0.082	–0.15
		P	***	***	0.069	0.054	0.054	0.83	0.097	0.019	0.012	0.064	*	***	0.92	0.39	0.11
CCT7	Tumor	R	–0.11	–0.026	–0.14	–0.15	–0.12	–0.14	–0.17	–0.2	0.063	0.052	–0.0082	–0.045	0.012	0.044	–0.083
		P	**	0.39	***	***	***	***	***	***	0.038	0.09	0.79	0.14	0.7	0.15	*
	Normal	R	0.28	0.39	0.18	0.16	0.15	–0.037	0.03	–0.4	0.012	–0.078	0.15	–0.35	0.11	0.03	–0.13
		P	*	***	0.053	0.091	0.12	0.7	0.75	***	0.9	0.41	0.11	***	0.26	0.75	0.16
CCT8	Tumor	R	–0.084	–0.055	–0.13	–0.11	–0.062	–0.12	–0.15	–0.081	0.012	0.069	0.0017	0.0034	–0.0033	0.11	0.059
		P	*	0.069	***	**	0.042	***	***	*	0.68	0.024	0.96	0.91	0.91	***	0.054
	Normal	R	0.54	2.1e−07	0.34	0.35	0.4	0.13	0.18	–0.17	0.056	–0.15	0.36	–0.35	0.076	0.22	–0.059
		P	***	0.47	**	**	***	0.17	0.055	0.07	0.56	0.11	***	***	0.43	0.022	0.54

Tfh, follicular helper T cell; TAM, tumor-correlated macrophage; R, R-value of Spearman’s correlation; P, P-value of Spearman’s correlation. *P < 0.01; **P < 0.001; ***P < 0.0001.