. 2021 Mar 17;15:637071. doi: 10.3389/fnhum.2021.637071

TABLE 2.

Clinical information of the subjects.

Group	Subject	Sex	Age	Course (years)	Epileptic Discharge site	Cause	Seizure type	Epilepsy Syndrome	MRI Lesion	Cathode	Anode	Seizure frequency (baseline/follow-up) unit: times/4 weeks)	Response (Y/N)
Active	1^a	M	30	17	Focal	Birth asphyxia and brain surgery	Focal clonic seizure	Epilepsy attributed to structural causes	Softening of left parietal lobe	Between C3-FC1	rSO^c	80/77	N
	2^a	M	27	2	Focal	Hippocampal sclerosis	Automatisms	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	F7	rSO	1/4	N
	3^a	M	54	40	Focal	Trauma	Focal onset to bilateral tonic-clonic seizure	Frontal lobe epilepsy	None	F4	P7	1/1	N
	4^a	M	54	40	Focal	Trauma	Focal onset to bilateral tonic-clonic seizure	Frontal lobe epilepsy	None	F4	P7	1/3	N
	5	F	37	6	Focal	Gray matter heterotopia	Automatisms	Epilepsy attributed to heterotopia	Subependymal gray matter heterotopia	F7	rSO	3/1	Y
	6	F	41	2	Focal	Hippocampal sclerosis	Behavior arrest	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	F7	rSO	10/14	N
	7	F	64	44	Focal	Hippocampal sclerosis	Automatisms, and focal onset to bilateral tonic-clonic seizure	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	F8	lSO^d	9/7	Y
	8^a	F	23	23	Focal	Cryptogenic	Behavior arrest	Epilepsy of unknown cause	None	Between C3-F3	rSO	7/14	N
	9	F	28	10	Multifocal^b	Viral encephalitis	Focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to infection	Bilateral temporal lobe atrophy	F7/F8	rSO/lSO	12/9	Y
	10^a	F	26	3	Multifocal^b	Gray matter heterotopia	Automatisms	Epilepsy attributed to heterotopia	Subependymal gray matter heterotopia	F7/F8	rSO/lSO	5/10	N
	11	M	30	26	Focal	Focal cortical dysplasia	Focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to focal cortical dysplasia	Focal cortical dysplasia in left frontal lobe	Between F4-Fz	P7	28/28	N
	12	M	64	10	Focal	Trauma	Focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to trauma	Softening of left temporal lobe	F7	rSO	1/0	Y
Sham	13^a	M	30	17	Focal	Hippocampal sclerosis	Automatisms	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	Between C3-FC1	rSO	56/66	/
	14	M	47	16	Focal	Trauma and cavernous hemangioma	Automatisms, and focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to structural causes	Cavernous hemangioma	CP6	lSO	2/2	/
	15^a	M	27	2	Focal	Focal cortical dysplasia	Focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to focal cortical dysplasia	Focal cortical dysplasia in left frontal lobe	F7	rSO	3/2	/
	16	F	61	53	Focal	Hippocampal sclerosis	Automatisms, and focal onset to bilateral tonic-clonic seizure	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	F7	rSO	6/8	/
	17	F	49	14	Focal	Meningitis	Automatisms, and focal onset to bilateral tonic-clonic seizure	Epilepsy attributed to infection	White matter lesions	Between C4-P4	lSO	2/1	/
	18^a	F	23	23	Focal	Cryptogenic	Behavior arrest	Epilepsy of unknown cause	None	Between C3-F3	rSO	14/9	/
	19	F	54	48	Focal	Poisoning and hippocampal sclerosis	Automatisms, and focal onset to bilateral tonic-clonic seizure	Mesial temporal lobe epilepsy with hippocampal sclerosis	Hippocampal sclerosis	F8	lSO	6/6	/
	20^a	F	26	3	Multifocal^b	Gray matter heterotopia	Automatisms	Epilepsy attributed to heterotopia	Subependymal gray matter heterotopia	F7/F8	rSO/lSO	6/4	/

^aThese subjects underwent two ctDCS sessions with an interval of at least 12 weeks.

^bThese subjects suffered from multifocal epilepsy. Each site was stimulated for 10 min per day.

^crSO means the right supraorbital area.

^dlSO means the left supraorbital area.