TABLE 5.
Intrinsic cardiac activities of perfused isolated hearts from the control, untreated MI, and pre-treated MI groups.
| Control | Untreated MI | Lipoic acid | Zinc | Clopidogrel | |
| HR (bpm) | |||||
| Baseline values | 220.33 ± 13.10(25) | 157.95 ± 13.90a(12) | 147.86 ± 16.30a(23) | 172.67 ± 16.39a(21) | 177.64 ± 19.29(24) |
| Maximal responses | 216.76 ± 11.72(24) | 199.82 ± 12.86*(10) | 150.38 ± 18.56ab(22) | 201.09 ± 18.60*(20) | 227.43 ± 12.53*(24) |
| Delta changes | −1.06 ± 7.75(24) | 51.47 ± 9.61a(10) | 8.62 ± 13.20b(22) | 39.45 ± 11.85a(20) | 49.79 ± 17.24a(24) |
| PT/LV (g/100 mg) | |||||
| Baseline values | 0.99 ± 0.16(25) | 0.73 ± 0.10(12) | 0.81 ± 0.19(23) | 0.73 ± 0.10(21) | 1.11 ± 0.11ab(24) |
| Maximal responses | 1.06 ± 0.10*(24) | 0.87 ± 0.12*(10) | 0.68 ± 0.09ab(22) | 0.74 ± 0.09a(20) | 1.18 ± 0.10ab(24) |
| Delta changes | 0.21 ± 0.08(24) | 0.17 ± 0.03(10) | 0.04 ± 0.02ab(22) | 0.11 ± 0.06(20) | 0.07 ± 0.04a(24) |
| TPT (msec) | |||||
| Baseline values | 63.89 ± 5.89(25) | 92.63 ± 6.30a(12) | 73.57 ± 6.76(23) | 59.17 ± 5.14b(21) | 122.14 ± 11.63ab(24) |
| Maximal responses | 52.94 ± 4.18*(24) | 67.06 ± 5.74*(10) | 70.77 ± 6.25a(22) | 46.36 ± 3.10*b(20) | 85.71 ± 8.37*a(24) |
| Delta changes | −10.00 ± 4.46(24) | −27.06 ± 5.99a(10) | −5.38 ± 5.38b(22) | −14.55 ± 5.29(20) | −36.43 ± 10.30a(24) |
| 1/2 RT (msec) | |||||
| Baseline values | 45.56 ± 3.90(25) | 38.95 ± 2.41(12) | 40.00 ± 2.57(23) | 38.33 ± 3.45(21) | 42.86 ± 2.66(24) |
| Maximal responses | 32.35 ± 2.19*(24) | 26.47 ± 2.09*(10) | 34.62 ± 3.51*b(22) | 28.18 ± 2.26*(20) | 32.86 ± 2.44*(24) |
| Delta changes | −14.12 ± 2.98(24) | −13.53 ± 2.56(10) | −5.38 ± 2.43ab(22) | −10.00 ± 2.70(20) | −10.00 ± 2.57(24) |
| MFR/LV (ml/min/100 mg) | |||||
| Baseline values | 2.23 ± 0.26(25) | 2.07 ± 0.24(12) | 1.96 ± 0.17(23) | 3.58 ± 0.57ab(21) | 2.18 ± 0.20(24) |
| Maximal responses | 2.30 ± 0.28(24) | 2.13 ± 0.27(10) | 1.81 ± 0.17(22) | 3.60 ± 0.68b(20) | 2.56 ± 0.28*(24) |
| Delta changes | 0.16 ± 0.09(24) | 0.16 ± 0.11(10) | −0.05 ± 0.07(22) | 0.02 ± 0.14(20) | 0.37 ± 0.12(24) |
Values are represented as mean ± SEM. The number of observations is given in parentheses. MI, myocardial infarction; HR, heart rate; PT/LV, peak tension/left ventricle; TPT, time to peak tension; 1/2RT, half-relaxation time; MFR/LV, myocardial flow rate/left ventricle. aSignificance of differences from control group calculated by Student’s t-test for unpaired data at p < 0.05. bSignificance of differences from MI group calculated by Student’s t-test for unpaired data at p < 0.05. * Significance of the maximal response to baseline value of the same group calculated by Student’s t-test for paired data at p < 0.05.