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. 2021 Mar 17;12:635016. doi: 10.3389/fmicb.2021.635016

TABLE 1.

Minimum inhibitory concentration (MIC), fractional inhibitory concentration (FIC), and FIC indices of linalool and meropenem against KPC-KP cells.

Combinations of linalool and meropenem (μg/ml) KPC-KP
Type of interaction
MICO FIC FICI FICIc
Linalool 11,250 5,625 0.50 1.00 Additive
Meropenem 32.00 16.00 0.50

MICO, MIC of one component alone; FIC, MIC of one component in the most effective combination; FICI, FIC index of one component in the most effective combination; FICIc, total FICI of the combination of both components. FICIc ≤ 0.5, synergistic; FICIc > 0.5–4.0, additive; FICIc > 4.0, antagonistic.