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. 2020 Apr 2;15(1):281–287. doi: 10.1007/s12105-020-01157-9

Table 1.

Literature review of Studies on Granular Cell Tumor between 1980 and 2018

Author Title Journal Year Findings
Mirza FN, Tuggle CT, Zogg CK, Mirza HN, Narayan D Epidemiology of Malignant Cutaneous Granular Cell Tumors: A United States population-based cohort analysis using the Surveillance, Epidemiology, and End Results (SEER) database J Am Acad Dermatol 2018 DSS for local, regional and distant mGTC: 20yrs, < 5 yrs, < 0.5yrs respectively
Moten AS, Movva S, von Mehren M, Wu H, Esnaola NF, Reddy SS, Farma JM Granular cell tumor experience at a comprehensive cancer center J Surg Res 2018 Institutional review of 50 GTC patients: 4% malignancy rate, 6% multifocal on presentation
Moten AS, Zhao H, Wu H, Farma JM Malignant granular cell tumor: Clinical features and long-term survival J Surg Oncol 2018 113 mGCT patients: 4.0 cm average T size, 13% lymph node metastasis, 11% distal metastasis, poorer survival in patients with T size > 5 cm
Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S Atypical and malignant granular cell tumors in Japan: a Japanese musculoskeletal oncology group (JMOG) study Int J Clin Oncol 2016 18 atypical & mGCTs reviewed: lymph node metastasis in 4/18 cases; 5 & 10 yr OS 52%, 26% respectively. 5 yr LRFS 69% with wide resection and 43% with marginal or intralesional resection
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation Am J Surg Pathol 1998 Reviewed 46 mGCT, 21 atypical GCT, 6 GCT: median T size in mGCT 4 cm, 1.5 cm in atypical and 2 cm in benign. 39% of mGCT died of disease at 3 yr median, local recurrence in 32%, metastasis in 50% (including lymph nodes)
Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B Granular cell tumor: A clinicopathologic study of 110 patients J Surg Onc 1980 Review of 110 GTC patients: 10% “clinically simulated a malignant neoplasm”-non pathologic diagnosis of mGTC, 5% multifocal on presentation