Fig. 4.

Follicular carcinoma/adenomas in PTEN Hamartoma syndrome: a Low magnification view of cellular follicular neoplasm with a thick fibrous capsule (HE, 40X). b The lesional cells demonstrated a “tight” microfollicular pattern bordering on solid/trabecular microarchitecture. The nuclei show mild pleomorphism and abundant eosinophilic to clear cytoplasm (HE, 200X). c Distinctive areas of capsular and vascular invasion were appreciated (HE, 40X). d Multiple small but distinctive and mostly unencapsulated hyperplastic nodules/microadenomas were scattered throughout both lobes (HE, 40X)