. 2021 Mar 30;11:7174. doi: 10.1038/s41598-021-86191-5

Table 5.

Multinominal linear regression analyses of LGMN score by lesion type and HLA-DR.

	N	%	Center			Edge			Peri-lesion
	N	%	B	95%CI	p	B	95%CI	p	B	95%CI	p
White matter lesions
LR χ²			F_{df 2} = 23.5, p < 0.001			F_{df 2} = 14.9, p = 0.001			F_{df 2,48} = 8.8, p = 0.001
Active	8	13.3%	4.00	[2.22,6.22]	< 0.001	2.70	[1.17,4.46]	0.001	1.60	[−0.53,3.87]	0.129
Chronic active	17	28.3%	1.60	[0.45,2.86]	0.008	1.60	[0.41,2.91]	0.011	1.50	[−0.29,3.64]	0.108
Chronic inactive*	35	58.3%	0*	–	–	0*	–	–	0*	–	–
Gray matter lesions
LR χ2			F_{df 3} = 7.6, p = 0.056			F_{df 3} = 3.7, p = 0.154			F_{df 3} = 1.6, p = 0.662
Type 1—leucocortical	11	17.7%	1.29	[−0.86,3.56]	0.248	1.74	[−0.45,4.05]	0.126	0.00	[−3.26,3.26]	< 1
Type 2—intracortical	16	25.8%	-1.47	[−3.42,0.41]	0.129	0.52	[−1.35,2.45]	0.593	1.39	[−1.21,4.31]	0.322
Type 3—subpial	28	45.2%	-0.90	[−2.56,0.75]	0.283	-0.01	[−1.67,1.72]	0.990	0.38	[−2.06,3.02]	0.770
Type 4—throughout cortex*	7	11.3%	0*	–	–	0*	–	–	0*	–	–
HLA-DR
LR χ²			F_{df 2} = 35.7, p < 0.001			F_{df 2} = 41.7, p < 0.001			F_{df 2} = 8.0, p = 0.018
Inactive	74	66.1%	0*	–	–	0*	–	–	0*	–	–
Reactive	29	25.9%	2.28	[1.35,3.28]	< 0.001	2.64	[1.67,3.7]	< 0.001	1.39	[0.07,2.83]	0.064
Active, amoeboid	9	8.0%	3.27	[1.83,4.8]	< 0.001	3.22	[1.82,4.71]	< 0.001	2.18	[0.43,3.91]	0.009

B coefficient, CI confidence interval, * reference category, LR χ2 loglinear chi square, Df degrees of freedom.

Significant p-values after sequential Bonferroni correction indicated in bold typeface.