Table 1.
Baseline characteristics of patients with stage IV GC.
| Characteristics | Total (%) N = 16,596 | BSC (%) N = 7282 | CHT + / − RT (%) N = 6819 | Gastrectomy (%) N = 1244 | Primary Gastrectomy (%) N = 1031 | Secondary Gastrectomy (%) N = 220 | p |
|---|---|---|---|---|---|---|---|
| Year of diagnosis | < 0.0001 | ||||||
| 2004–2006 | 4037 (24.3) | 1917 (26.3) | 1287 (18.9) | 454 (36.5) | 355 (34.4) | 24 (10.9) | |
| 2007–2010 | 5493 (33.1) | 2402 (33) | 2206 (32.4) | 435 (35) | 384 (37.2) | 66 (30) | |
| 2011–2015 | 7066 (42.6) | 2963 (40.7) | 3326 (48.8) | 355 (28.5 | 292 (28.3) | 130 (59.1) | |
| Sex | 0.083 | ||||||
| Male | 9454 (57) | 4149 (57) | 3907 (57.3) | 701 (56.4) | 592 (57.4) | 105 (47.7) | |
| Female | 7142 (43) | 3133 (43) | 2912 (42.7) | 543 (43.6) | 439 (42.6) | 115 (52.3) | |
| Age | < 0.0001 | ||||||
| < 65 | 7646 (46.1) | 2503 (34.4) | 3948 (57.9) | 413 (33.2) | 630 (61.1) | 152 (69.1) | |
| ≥ 65 | 8950 (53.9) | 4779 (65.6) | 2871 (42.1) | 831 (66.8) | 401 (38.9) | 68 (30.9) | |
| Race | |||||||
| White | 11,108 (67) | 4865 (67) | 4664 (68.7) | 803 (64.6) | 637 (61.9) | 139 (63.8) | < 0.0001 |
| Black | 2684 (16.3) | 1233 (17) | 1072 (15.8) | 191 (15.4) | 157 (15.3) | 31 (14.2) | |
| Other | 2748 (16.7) | 1160 (16) | 1056 (15.5) | 249 (20) | 235 (22.8) | 48 (22) | |
| Marital status | < 0.0001 | ||||||
| Unmarried | 9208 (55.4) | 3506 (48.1) | 4201 (61.6) | 696 (55.9) | 661 (64.1) | 144 (65.5) | |
| Married | 6681 (40.3) | 3436 (47.2) | 2347 (34.4) | 497 (40) | 339 (32.9) | 62 (28.2) | |
| Unknown | 707 (4.3) | 340 (4.7) | 271 (4) | 51 (4.1) | 31 (3) | 14 (6.4) | |
| Insurance status | < 0.0001 | ||||||
| Insured | 11,533 (69.5) | 4866 (66.8) | 5122 (75.1) | 733 (58.9) | 627 (60.8) | 185 (84.1) | |
| Uninsured | 4767 (28.7) | 2253 (30.9) | 1599 (23.4) | 490 (39.4) | 392 (38) | 33 (15) | |
| Unknown | 296 (1.8) | 163 (2.2) | 98 (1.4) | 21 (1.7) | 12 (1.2) | 2 (0.9 | |
| Performance status | < 0.0001 | ||||||
| Good | 10,212 (61.5) | 3567 (49) | 5024 (73.7) | 639 (51.4) | 797 (77.3) | 185 (84.1) | |
| Poor | 6384 (38.5) | 3715 (51) | 1795 (26.3) | 605 (48.6) | 234 (22.7) | 35 (15.9) | |
| Complicated disease | < 0.0001 | ||||||
| No | 5748 (34.6) | 2007 (27.6) | 2235 (32.8) | 743 (59.7) | 630 (61.1) | 133 (60.5) | |
| Yes | 10,848 (65.4) | 5275 (72.4) | 4584 (67.2) | 501 (40.3) | 401 (38.9) | 87 (39.5) | |
| Site of tumor | < 0.0001 | ||||||
| Fundus-Body | 3345 (20.2) | 1440 (19.8) | 1537 (22.5) | 167 (13.4) | 146 (14.2) | 55 (25) | |
| Antrum-Pylorus | 4026 (24.2) | 1651 (22.7) | 1440 (21.1) | 481 (38.7) | 400 (38.8) | 54 (24.5) | |
| Overlapping lesion of the stomach | 2191 (13.2) | 862 (11.8) | 962 (14.) | 170 (13.7) | 147 (14.3) | 50 (22.7) | |
| Stomach, NOS | 7034 (42.4) | 3329 (45.7) | 2880 (42.2) | 426 (34.1) | 338 (32.8) | 61 (27.7) | |
| Histology | < 0.0001 | ||||||
| Adenocarcinoma/carcinoma, NOS | 8912 (537) | 4394 (60.3) | 3562 (52.2) | 524 (42.1) | 373 (36.2) | 59 (26.8) | |
| Signet ring cell adenocarcinoma | 4387 (26.4) | 1619 (22.2) | 2059 (30.2) | 305 (24.5) | 318 (30.8) | 86 (39.1)) | |
| Linitis plastica | 1113 (6.7) | 83 (1.1) | 91 (1.3) | 25 (2) | 16 (1.6) | 5 (2.3) | |
| Adenocarcinoma, intestinal type | 751 (4.5) | 424 (5.8) | 372 (5.5) | 150 (12.1) | 140 (13.6) | 27 (12.3) | |
| Adenocarcinoma, diffuse type | 220 (1.3) | 251 (3.4) | 296 (4.3) | 92 (7.4) | 88 (8.5) | 24 (10.9) | |
| Other | 1213 (7.3) | 511 (7) | 439 (6.4) | 148 (11.9) | 96 (9.3) | 19 (8.6) | |
| T stage, 8th ed | < 0.0001 | ||||||
| Tx | 6736 (40.6) | 3637 (49.9) | 3036 (44.5) | 28 (2.3) | 32 (3.1) | 3 (1.4) | |
| T1-2 | 3195 (19.3) | 1513 (20.8) | 1512 (22.2) | 81 (6.5) | 66 (6.4) | 23 (10.4) | |
| T3-4 | 6665 (40.1) | 2132 (29.3) | 2271 (33.3) | 1135 (91.2) | 933 (90.5) | 194 (88.2) | |
| N stage, 8th ed | < 0.0001 | ||||||
| N0 | 5744 (34.6) | 2870 (39.4) | 2519 (36.9) | 180 (14.5) | 139 (13.5) | 36 (16.4) | |
| N1-2 | 5211 (31.4) | 1843 (25.3) | 2397 (35.2) | 473 (38) | 390 (37.8) | 108 (49.1) | |
| N3 | 1293 (7.8) | 69 (0.9) | 136 (2) | 539 (43.3) | 474 (46) | 75 (34.1) | |
| Nx | 4348 (26.2) | 2500 (34.3) | 1767 (25.9) | 52 (4.2) | 28 (2.7) | 1 (0.5) | |
| Grade | < 0.0001 | ||||||
| Well/moderate differentiated | 2571 (15.5) | 1171 (16.1) | 963 (14.1) | 249 (20) | 164 (15.9) | 24 (10.9) | |
| Poorly/undifferentiated | 9925 (59.8) | 4944 (53.5) | 4109 (60.3) | 924 (74.5) | 816 (79.2) | 180 (81.9) | |
| Unknown | 4100 (24.7) | 2217 (30.4) | 1747 (25.6) | 69 (5.5) | 51 (4.9) | 16 (7.2) | |
| Metastatic spread | < 0.0001 | ||||||
| Distant lymphnodes | 1478 (8.9) | 511 (7) | 625 (9.2) | 145 (11.7) | 158 (15.3) | 39 (17.7) | |
| Distant metastases | 12,421 (74.8) | 5605 (77) | 4868 (71.4) | 1002 (80.5) | 787 (76.3) | 159 (72.3) | |
| Distant lymphnodes + metastases | 2697 (16.3) | 1166 (16) | 1326 (49.2) | 97 (3.6) | 86 (3.2) | 22 (10) | |
| Type of gastrectomy | < 0.0001 | ||||||
| Partial gastrectomy | 951 (76.4) | 760 (73.7) | 129 (58.6) | ||||
| Total (or near-total) gastrectomy | 293 (23.6) | 271 (26.3) | 91 (41.4) | ||||
| Number of retrieved lymphnodes | < 0.0001 | ||||||
| ≤ 15 | 801 (64.4) | 590 (57.2) | 111 (50.5) | ||||
| > 15 | 443 (35.6) | 441 (42.8) | 109 (49.5) | ||||
| Radical intent | < 0.0001 | ||||||
| No | 620 (49.8) | 426 (41.3) | 81 (36.8) | ||||
| Yes | 624 (50.2) | 605 (58.7) | 139 (63.2) | ||||
| Response to NAT* | |||||||
| Regression | 48 (21.8) | ||||||
| Stable | 103 (46.8) | ||||||
| Progression | 69 (31.4) | ||||||
| Response to chemotherapy | |||||||
| No | 4260 (62.5) | ||||||
| Yes | 2559 (37.5) |
Statistically significant p values are given in bold
NOS Not otherwise specified.
*NAT: Neo-adjuvant chemotherapy.