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. 2021 Mar 30;11:7169. doi: 10.1038/s41598-021-86170-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CSF analysis. The dichotomized categorization into abnormal (left) vs. normal (right) CSF was made according to the middle dark grey box's criteria. Cases can have more than one positive parameter; therefore, the sum of all findings does not add up to 100% of cases. The reported proportions are percentages of the entire cohort (n = 144). Age-dependent CSF NfL cutoffs were used according to Yilmaz²⁸ (see also Supplementary Table 1). All cases were then analyzed using further examination results described in the operationalized group assignment procedure (see Fig. 1 for details).