Table 2.
Cerebrospinal fluid (CSF) findings.
| Group | Cell count: white blood cells [/µl] (n = 144) | Cell count: red blood cells [1000/µl] (n = 144) | Total protein [mg/dl] (n = 144) | Quotient CSF/serum albumin (n = 125) | Quotient CSF/serum IgG (n = 125) | Oligoclonal bands (n = 99) | Total-tau [pg/ml] (n = 61) | Phospho-tau [pg/ml] (n = 59) | Abeta 1–42 [pg/ml] (n = 61) | Neurofilament light chain (NfL) [pg/ml] (n = 42) |
|---|---|---|---|---|---|---|---|---|---|---|
| F2 (n = 84) | 1.83 ± 1.3 [0–6] | 0.15 ± 0.50 [0–3] | 35 ± 11 [13–72] | 5.9 ± 2.0 [1.9–11.5] | 2.7 ± 1.0 [0.8–5.8] | type I: n = 36, type IV: n = 9 | 221 ± 102 [37–453] n = 35 | 39 ± 17 [15–73] n = 34 | 984 ± 242 [302–1417] n = 35 | 358 ± 176 [127–828] n = 26 |
| F1/F3-F6 (n = 22) | 1.52 ± 1.0 [0–4] | 0.32 ± 1.5 [0–7] | 39 ± 14 [22–75] | 6.5 ± 2.8 [2.2–12.3] | 3.0 ± 1.2 [0.8–5.4] | type I: n = 6, type IV: n = 3 | 282 ± 117[67–452] n = 10 | 44 ± 14[15–56] n = 9 | 805 ± 158 [594–1120] n = 10 | 375 ± 117 [288–508] n = 3 |
| F06.2 (n = 17) | 6.65 ± 10.1 [0–42] | 0.50 ± 1.6 [0–6] | 36 ± 14 [16–66] | 6.9 ± 2.9 [2.9–13.2] | 3.8 ± 2.5 [1.2–9.4] | type I: n = 4, type II: n = 4, type III: n = 1, type IV: n = 1 | 240 ± 99.5 [153–421] n = 6 | 42 ± 16 [30–64] n = 6 | 794 ± 236 [586–1166] n = 6 | 799 ± 752 [236–2080] n = 6 |
| "No reliable classification" (n = 21) | 1.48 ± 0.98 [0–3] | 0 ± 0 [0–0] | 36 ± 14 [19–82] | 5.9 ± 2.75 [2.5–14.1] | 3.1 ± 2.0 [1.3–10.2] | type I: n = 2, type II: n = 4, type III: n = 2, type IV: n = 4 | 231 ± 67 [129–347] n = 10 | 40 ± 12 [24–56] n = 10 | 994 ± 244 [636–1392] n = 10 | 764 ± 630 [321–1782] n = 7 |
| p–values (F2 vs. F06.2) | 0.008 | 0.68 | 0.76 | 0.58 | 0.33 | < 0.00001 | 0.61 | 0.75 | 0.074 | 0.33 |
| Gaussian variable | No | No | No | No | No | Nominal | Yes | Yes | Yes | No |
All values are reported as mean ± standard deviation, range [minimum–maximum]. All variables were non-Gaussian variables and therefore tested using the Mann–Whitney-U-Test; two-sided significance level was used. OCB group differences were analyzed using Pearson's chi-square test. This data analysis was exploratory, no correction for multiple testing was applied. Bold items are below an alpha of 5%. Abbreviations: CSF: cerebrospinal fluid, OCBs: oligoclonal bands.