Table 2.
Biochemistry data of patients on the day of sampling for detection of SARS-CoV-2 RNA in plasma. RNAemia was defined as SARS-CoV-2 RNA copies > 1000/ml plasma.
| Patients with RNAemia (n = 29) | Patients without RNAemia (n = 59) | p-value | |
|---|---|---|---|
| Blood hemoglobin (g/L) | 120 (109–130) | 119 (103–126) | n.s |
| Blood leukocyte count (× 109/L) | 7.3 (6.0–9.6) | 8.3 (6.3–11) | n.s |
| Blood neutrophil granulocyte count (× 109/L) | 5.9 (5.1–7.4) | 5.8 (4.8–8.8) | n.s |
| Blood lymphocyte count (× 109/L) | 1.0 (0.65–1.3) | 1 (0.7–1.3) | n.s |
| Blood platelet count (× 109/L) | 270 (199–334) | 307 (227–380) | n.s |
| Plasma C-reactive protein (mg/L) | 210 (131–309) | 216 (141–299) | n.s |
| Plasma procalcitonin (µg/L) | 0.6 (0.3–1.6) | 0.53 (0.26–1.8) | n.s |
| Plasma interleukin-6 (ng/L) | 180 (114–331) | 108 (58–272) | 0.046 |
| Plasma ferritin (µg/L) | 1539 (545–2571) | 2105 (971–3052) | n.s |
| Plasma fibrin D-dimer (mg/L FEU) | 1.6 (1.1–3.0) | 1.7 (1.3–3.1) | n.s |
| Plasma ALT (µkat/L) | 0.67 (0.42–0.99) | 0.93 (0.45–1.48) | n.s |
| Plasma AST (µkat/L) | 1.3 (0.71–1.79) | 1.19 (0.73–1.61) | n.s |
| Plasma bilirubin (µmol/L) | 10 (8–11) | 10 (8–15) | n.s |
| Plasma lactate dehydrogenase (µkat/L) | 6 (5–8) | 6 (5–7) | n.s |
| Plasma N-terminal pro-BNP (ng/L) | 360 (233–504) | 340 (121–842) | n.s |
| Plasma Troponin I (ng/L) | 11 (7.1–42) | 8.2 (3.9–25) | n.s |
| Plasma creatinine (µmol/L) | 86 (64–103) | 71 (61–100) | n.s |
| eGFRCystC (mL/min/1.73 m2 BSA) | 58 (42–76) | 58 (40–72) | n.s |
| eGFRCrea (mL/min/1.73 m2 BSA) | 67 (51–83) | 75 (55–80) | n.s |
Data are expressed as median (interquartile range, IQR). Groups compared with Mann-Whiney U test. Laboratory data missing for 4 cases. Abbreviations: ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, BNP: Brain natriuretic peptide, BSA: Body surface area, eGFRCystC: Estimated glomerular filtration rate from plasma cystatin C, eGFRCrea: Estimated glomerular filtration rate from plasma creatinine, FEU: fibrinogen equivalent units, SOFA: Sequential Organ Failure Assessment.