Table 1.

Frequencies of chest HRCT findings in study participants.

	Total (n = 311)	S-LAM (n = 272) n (%)	TSC-LAM (n = 39) n (%)	P value
Age at presentation (y) Mean ± SD	39.1 ± 9.4	39.2 ± 9.2	38.3 ± 10.3	P = 0.481
Median (range)	38 (19 – 71)	38 (19 – 71)	36 (21 – 66)
Cyst appearance
Common appearance* alone	254 (81.7%)	223 (82.0%)	31 (79.5%)	P = 0.706
Common appearance + large   cysts†	52 (16.7%)	44 (16.2%)	8 (20.5%)	P = 0.497
Common appearance + cysts with irregularly thickened walls	2 (0.6%)	2 (0.7%)	0
Multiple thin-walled cysts, mostly large	2 (0.6%)	2 (0.7%)	0
Multiple thin-walled cysts, mostly irregularly shaped	1 (0.3%)	1 (0.4%)	0
Findings in addition to cysts
Lymphatic congestion	24 (7.7%)	20 (7.4%)	4 (10.3%)
Lobar area	16 (5.1%)	12 (4.4%)	4 (10.3%)
Limited area	6 (1.9%)	6 (2.2%)	0
Mediastinal area	2 (0.6%)	2 (0.7%)	0
Diffuse noncalcified nodules¶	6 (1.9%)	6 (2.2%)	0
with small cavitary changes	4 (1.3%)	4 (1.5%)	0
with ground-glass attenuation	3 (1.0%)	3 (1.1%)	0
TSC-related findings
Rounded ground-glass  opacities suggestive of MMPH	15 (4.8%)	1 (0.4%)	14 (35.9%)	P < 0.001
Myocardial fatty foci	26 (8.4%)	8 (2.9%)	18 (46.1%)	P < 0.001
Bone nodules	60 (19.3%)	28 (10.3%)	32 (82.1%)	P < 0.001

HRCT high resolution computed tomography, LAM lymphangioleiomyomatosis, MMPH multifocal micronodular pneumocyte hyperplasia, SD standard deviation, S-LAM sporadic LAM, TSC-LAM tuberous sclerosis complex-associated LAM, y years of age.

*Common appearance is multiple thin-walled oval-shaped pulmonary cysts distributed evenly throughout both lung fields.

^†Large cysts are those > 2 cm.

^¶One patient had diffuse nodules with both small cavitary changes and ground-glass opacities.