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. 2021 Mar 17;8:604392. doi: 10.3389/fmed.2021.604392

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Copyright © 2021 Li, Li, Ge, Du, Li, Li, Zhang, Tan, Zhang, Yuan, Zhang, Zhang, Liu, Ding, Sun, Chen, Wang, Shen and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical validation of SARS-CoV-2 detection in breath samples with comparison to Lab testing. (A) Quantitative plot of sampling time vs. virus concentration from detection tests of the Lab and collected clinical samples, where the Lab samples are sampling time-dependent tests with a fixed virus concentration at 10,000 copies/mL and concentration-dependent tests with a fixed sampling time of half an hour, while the shaded area indicates the detection range of the current method based on Lab tests, with the equation of the threshold boundary line ct = 42,000 (s·copies/mL), midway between the 18,000 and 100,000 lines. (B) Lab sampling device with a pump installed inside. (C) Disposable collection tube applied in the real POC clinical test.