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. 2021 Mar 17;8:634177. doi: 10.3389/fmed.2021.634177

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Copyright © 2021 Gu, Huang, Avula, Caruso, Drysdale, Vessey, Ou, Fowler, Liu, Lin, Horton, Masters, Wiley, Guymer and Fletcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phagocytic function in participants with and without reticular pseudodrusen (A) Fundus auto-fluorescence (FAF; top) and near Infrared reflectance (NIR; bottom) spectroscopy images showing reticular pseudodrusen (RPD) area outlined using Image J software. (B) Graph showing mean+standard deviation of monocyte phagocytosis in healthy controls (HC, n = 35), subjects with intermediate AMD without RPD (RPD⁻; n = 42) and intermediate AMD with RPD (RPD⁺; n = 18). P-values from One-way ANOVA analysis and Tukey's multiple comparisons tests are shown for comparison between specific groups. (C) Correlations of basal phagocytic function of three monocyte subsets with RPD area (n = 60). There was no significant correlation between phagocytosis and drusen area for any of the monocytes examined.