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. 2021 Mar 17;8:634177. doi: 10.3389/fmed.2021.634177

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Copyright © 2021 Gu, Huang, Avula, Caruso, Drysdale, Vessey, Ou, Fowler, Liu, Lin, Horton, Masters, Wiley, Guymer and Fletcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Phagocytic function and leukocyte biomarkers with potential diagnosis values for AMD. Top potential variables for diagnosis of AMD are shown in the table. AUC, area under curve of Receiver Operating Characteristic (ROC); Mono, monocytes; exp, surface expression; SD, standard deviation; phago, phagocytic function. Binary logistic regression was performed among selected multiple variables to create predicted probabilities for ROC analysis. ROC curves distinguishing between (A) healthy controls (HC) and all AMD (intermediate, GA and CNV) and (B) HC and intermediate AMD are shown. P-values are for asymptotic significance calculated by SPSS v24.