Figure 5.

Anti-tumor activity of the murine IgG2b antibody A24 in xenograft mouse models. (A) Kaplan–Meier survival curve of athymic nude mice bearing s.c. MCL UPN1 tumors treated with a single (i.v.) dose of 40 mg/kg A24 (10 mice) or vehicle control (9 mice). Treatment was initiated when tumors were about 5 mm in diameter. This figure was reprinted by permission from the American Association for Cancer Research: Lepelletier et al. (119). (B) Kaplan–Meier survival curve of the percentage of tumor-free mice among mice treated with vehicle control, A24 (single i.p. dose of 40 mg/kg), or DFO (20 mg 5 times per week) after s.c. xenograft with AML HL60 cells (n = 4 in each group). The p-value was determined using the log-rank test. One representative experiment of three is shown. © 2010 Callens et al. (128).