Table 3.

Hematology and clinical chemistry of rats administered Lacprodan® BLG for 13 weeks.

Parameter	Male dose groups (mg/kg bw)				Female dose groups (mg/kg bw)
	Control	100	300	1000	Control	100	300	1000
Hematology
Hematocrit (%)	48.71 ± 1.41	48.87 ± 1.80	50.61 ± 2.74	49.89 ± 2.17	45.23 ± 2.42	45.84 ± 1.57	45.91 ± 3.01	48.78 ± 2.12**
Hemoglobin (g/dL)	15.43 ± 0.47	15.57 ± 0.59	16.17 ± 0.68*	16.03 ± 0.50	14.39 ± 0.81	14.72 ± 0.37	14.74 ± 0.76	15.58 ± 0.67**
RBC (1012/L)	9.20 ± 0.23	9.27 ± 0.27	9.71 ± 0.70	9.55 ± 0.39	8.09 ± 0.58	8.24 ± 0.32	8.29 ± 0.37	8.92 ± 0.38***
MCV (fL)	52.98 ± 1.64	52.70 ± 0.72	52.21 ± 1.41	52.27 ± 1.49	55.98 ± 1.45	55.68 ± 0.83	55.35 ± 1.66	54.72 ± 1.17
MCH (pg/erythrocyte)	16.77 ± 0.65	16.80 ± 0.24	16.70 ± 0.69	16.80 ± 0.53	17.80 ± 0.42	17.89 ± 0.57	17.79 ± 0.45	17.48 ± 0.23
MCHC (g/dL)	31.70 ± 0.54	31.85 ± 0.33	31.97 ± 0.63	32.17 ± 0.50	31.83 ± 0.42	32.14 ± 0.87	32.12 ± 0.65	31.93 ± 0.77
Reticulocytes (%)	1.66 ± 0.30	1.59 ± 0.22	1.48 ± 0.25	1.40 ± 0.22	2.15 ± 0.74	1.82 ± 0.19	2.07 ± 0.42	1.77 ± 0.39
Thrombocytes (109/L)	684.0 ± 54.7	670.8 ± 64.0	694.4 ± 53.0	649.8 ± 69.3	693.0 ± 61.3	706.2 ± 86.1	699.5 ± 109.1	737.9 ± 86.3
WBC (109/L)	4.29 ± 0.99	3.46 ± 1.06	5.25 ± 0.85	5.13 ± 2.23	1.98 ± 0.65	2.25 ± 0.99	1.96 ± 0.73	2.55 ± 0.86
Neutrophils (%)	24.82 ± 6.93	23.32 ± 5.37	23.80 ± 11.06	22.74 ± 12.30	29.13 ± 23.25	24.44 ± 14.90	18.82 ± 8.15	22.71 ± 17.85
Lymphocytes (%)	71.93 ± 6.32	73.32 ± 5.32	73.40 ± 11.64	73.64 ± 12.67	68.54 ± 23.48	72.59 ± 16.38	77.22 ± 10.87	74.04 ± 19.61
Monocytes (%)	2.49 ± 0.86	2.64 ± 0.83	2.02 ± 0.56	2.75 ± 0.86	1.62 ± 0.68	2.22 ± 1.11	2.42 ± 0.79	2.24 ± 1.03
Eosinophils (%)	0.389 ± 0.209	0.470 ± 0.183	0.420 ± 0.274	0.400 ± 0.306	0.390 ± 0.242	0.570 ± 0.660	1.230 ± 2.775	0.700 ± 1.026
Basophils (%)	0.078 ± 0.067	0.070 ± 0.068	0.110 ± 0.057	0.110 ± 0.088	0.110 ± 0.088	0.070 ± 0.095	0.100 ± 0.082	0.089 ± 0.078
Luc (%)	0.256 ± 0.194	0.180 ± 0.123	0.230 ± 0.134	0.330 ± 0.183	0.170 ± 0.134	0.120 ± 0.092	0.220 ± 0.092	0.233 ± 0.132
Blood coagulation
Prothrombin time (sec)	23.76 ± 1.37	23.90 ± 1.33	23.78 ± 1.73	24.77 ± 1.78	24.54 ± 0.78	25.35 ± 1.74	24.94 ± 1.69	25.56 ± 0.79
aPTT (sec)	10.75 ± 0.92	11.32 ± 1.52	10.14 ± 1.58	9.96 ± 1.42	8.99 ± 0.73	9.02 ± 0.69	9.16 ± 0.77	9.23 ± 1.54
Clinical chemistry
ALAT (U/L)	34.03 ± 5.62	32.26 ± 3.43	30.60 ± 4.27	32.73 ± 9.06	28.77 ± 3.90	29.12 ± 5.48	28.54 ± 7.37	27.35 ± 4.10
ASAT (U/L)	99.06 ± 9.30	86.40 ± 11.83	86.41 ± 12.88	102.94 ± 43.36	89.55 ± 10.28	87.95 ± 13.21	80.63 ± 16.25	83.28 ± 20.08
AP (U/L)	111.2 ± 26.9	104.1 ± 22.5	102.8 ± 24.6	104.1 ± 20.3	55.59 ± 17.83	48.87 ± 21.20	44.09 ± 13.38	56.15 ± 29.63
Creatinine (μmol/L)	24.30 ± 2.45	26.10 ± 13.49	22.80 ± 8.08	40.60 ± 56.26	27.30 ± 3.06	24.40 ± 3.34	24.30 ± 2.95	23.80 ± 4.21
Total protein (g/L)	55.68 ± 2.58	55.31 ± 1.70	55.99 ± 2.07	54.76 ± 1.87	60.26 ± 1.80	60.56 ± 2.72	59.99 ± 3.04	58.27 ± 3.46
Albumin (g/L)	31.18 ± 1.34	30.82 ± 0.80	30.85 ± 0.65	30.70 ± 0.95	34.73 ± 1.46	34.65 ± 1.39	34.17 ± 1.86	33.27 ± 2.38
Urea (mmol/L)	7.75 ± 1.23	7.33 ± 1.29	7.41 ± 1.00	8.22 ± 3.87	7.79 ± 0.66	7.52 ± 1.29	7.32 ± 1.19	7.26 ± 1.13
Bilirubin (μmol/L)	1.96 ± 0.18	2.25 ± 0.61	2.07 ± 0.19	2.30 ± 0.32	2.39 ± 0.24	2.59 ± 0.40	2.85 ± 0.46*	2.93 ± 0.51*
Bile acids (μmol/L)	30.79 ± 10.25	34.95 ± 21.55	26.18 ± 10.50	27.71 ± 13.04	30.02 ± 10.52	23.52 ± 10.28	44.21 ± 41.75	42.14 ± 28.09
Cholesterol (mmol/L)	1.65 ± 0.37	1.72 ± 0.34	1.50 ± 0.21	1.61 ± 0.27	1.31 ± 0.23	1.42 ± 0.25	1.62 ± 0.55	1.37 ± 0.21
LDL (mmol/L)	0.458 ± 0.164	0.492 ± 0.178	0.345 ± 0.099	0.431 ± 0.087	0.294 ± 0.072	0.336 ± 0.094	0.444 ± 0.245	0.363 ± 0.088
HDL (mmol/L)	1.09 ± 0.21	1.11 ± 0.26	1.04 ± 0.14	1.06 ± 0.19	0.95 ± 0.17	1.04 ± 0.17	1.12 ± 0.31	0.95 ± 0.14
Triglycerides (mmol/L)	0.488 ± 0.176	0.583 ± 0.165	0.577 ± 0.150	0.601 ± 0.151	0.315 ± 0.115	0.234 ± 0.072	0.280 ± 0.046	0.259 ± 0.071
Glucose (mmol/L)	11.09 ± 2.77	8.52 ± 1.25**	9.62 ± 1.25	10.41 ± 1.44	6.55 ± 1.66	5.93 ± 1.44	5.99 ± 1.87	7.60 ± 4.06
Sodium (mmol/L)	142.3 ± 2.00	141.1 ± 3.11	140.7 ± 1.83	141.2 ± 1.93	142.7 ± 3.5	143.9 ± 3.2	142.7 ± 1.8	143.5 ± 2.6
Potassium (mmol/L)	4.02 ± 0.24	4.14 ± 0.28	4.38 ± 0.88	4.48 ± 1.01	3.76 ± 0.31	3.57 ± 0.36	4.15 ± 1.48	4.31 ± 1.44
Hormones
T3 (ng/mL)	3.35 ± 0.71	3.42 ± 0.77	3.75 ± 0.81	3.94 ± 0.53	3.33 ± 0.86	3.21 ± 1.36	3.56 ± 0.84	3.68 ± 1.32
T4 (ng/mL)	56.73 ± 4.86	55.30 ± 13.76	56.28 ± 8.02	55.97 ± 9.71	31.47 ± 6.62	31.67 ± 8.04	36.65 ± 9.37	38.01 ± 10.36
TSH (ng/mL)	2.77 ± 0.99	2.32 ± 0.78	2.03 ± 0.63	1.75 ± 0.57*	1.57 ± 1.12	1.40 ± 0.78	1.66 ± 0.76	1.36 ± 0.64
FSH (ng/mL)	5.71 ± 3.24	4.18 ± 2.02	4.39 ± 2.28	4.04 ± 2.67	2.98 ± 2.33	4.18 ± 3.76	4.16 ± 3.70	1.89 ± 1.69
LH (ng/mL)	0.46 ± 0.37	0.36 ± 0.27	0.43 ± 0.52	0.46 ± 0.31	1.60 ± 0.43	1.02 ± 0.44	1.60 ± 1.37	1.24 ± 0.66
Estradiol (ng/mL)	0.10 ± 0.07	0.12 ± 0.12	0.07 ± 0.04	0.16 ± 0.12	0.14 ± 0.13	0.07 ± 0.03	0.15 ± 0.07	0.15 ± 0.12
Testosterone (ng/mL)	0.92 ± 0.74	1.11 ± 0.56	1.27 ± 0.78	1.62 ± 1.53	0.54 ± 0.48	0.40a	0.73 ± 0.33	0.58 ± 0.24

Results are expressed as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 as compared with control.

RBC = red blood cell count; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; WBC = total white blood cell count; Luc = large unstained cells; aPTT = activated partial thromboplastin time; ALAT = alanine aminotransferase; ASAT = aspartate aminotransferase; AP = alkaline phosphatase; LDL = low density lipoprotein; HDL = high density lipoprotein.

^aBased on one animal.