Table 4.
Cox proportional hazards regression for any recurrence within 5 years.
| Term | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| (a) Genetic model | ||||
| Age | 1.00 (0.98–1.03) | 0.82 | 1.01 (0.98–1.04) | 0.644 |
| Grade | ||||
| I | Reference | Reference | ||
| II | 2.96 (1.04–8.40) | 0.042 | 3.27 (0.97–10.9) | 0.055 |
| III | 4.77 (1.44–15.83) | 0.012 | 4.59 (1.13–18.7) | 0.033 |
| Tumor Stage | ||||
| 1 | Reference | Reference | ||
| 2 | 1.63 (0.85–3.13) | 0.139 | 1.16 (0.57–2.32) | 0.681 |
| 3 | 1.11 (0.25–4.82) | 0.893 | 1.42 (0.32–6.29) | 0.644 |
| LVI | ||||
| No | Reference | Reference | ||
| Yes | 0.97 (0.48–1.98) | 0.936 | 0.69 (0.32–1.50) | 0.356 |
| Risk classification | ||||
| Low risk | Reference | Reference | ||
| High risk | 5.63 (2.77–11.5) | <0.001 | 5.56 (2.62–11.8) | <0.001 |
| (b) Clinicogenetic model | ||||
| Age | 1.01 (0.98–1.04) | 0.388 | 0.99 (0.97–1.02) | 0.692 |
| Grade | ||||
| I | Reference | Reference | ||
| II | 3.42 (1.04–11.3) | 0.043 | 2.58 (0.76–8.81) | 0.128 |
| III | 5.93 (1.53–22.9) | 0.009 | 4.49 (1.08–18.7) | 0.039 |
| Tumor Stage | ||||
| 1 | Reference | Reference | ||
| 2 | 1.54 (0.79–2.99) | 0.203 | 1.08 (0.53–2.23) | 0.825 |
| 3 | 1.09 (0.25–4.78) | 0.900 | 2.54 (0.56–11.5) | 0.224 |
| LVI | ||||
| No | Reference | Reference | ||
| Yes | 0.97 (0.46–2.06) | 0.943 | 0.79 (0.36–1.72) | 0.552 |
| Risk classification | ||||
| Low risk | Reference | Reference | ||
| High risk | 8.02 (3.52–18.3) | <0.001 | 19.8 (5.96–65.87) | <0.001 |
CI, confidence interval; HR, hazard ratio; LVI, lymphovascular invasion.