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. 2021 Mar 17;11:642170. doi: 10.3389/fonc.2021.642170

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Copyright © 2021 Hinterleitner, Zhou, Tandler, Heitmann, Kropp, Hinterleitner, Koch, Hartkopf, Zender, Salih and Maurer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of BAFF-R (TNFRSF13C), BCMA (TNFRSF17) and TACI (TNFRSF13B) in breast cancer patients and association with survival. (A–C) Association of BAFF-R (A), BCMA (B) and TACI (C) mRNA expression with patient survival was calculated using the TCGA Research Network database. Gene expression was analyzed from tumor tissue of 1,006 patients. Low and high expression was defined according to the respective median mRNA levels of the entire cohort. (D) Specific fluorescence intensity (SFI, defined as fold change ‘specific signal obtained by specific antibody’/’signal obtained by respective control’) of BAFF-R, BCMA and TACI surface expression of platelets from 10 HD and 10 breast cancer patients were determined by flow cytometry.