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. 2021 Mar 17;11:642170. doi: 10.3389/fonc.2021.642170

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Copyright © 2021 Hinterleitner, Zhou, Tandler, Heitmann, Kropp, Hinterleitner, Koch, Hartkopf, Zender, Salih and Maurer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of platelet-derived TACI (pTACI). (A, B) Immunofluorescence analysis of pTACI (green) and CD61 (red) expression in platelets from representative HD. White arrows highlight TACI expression in HD and breast cancer patients. (A) and breast cancer patient (B). (C) Gating strategy used to analyze platelets ex vivo. (D) Surface pTACI level of platelets derived from HD and breast cancer patients were determined by flow cytometry. Representative results obtained from HD and breast cancer patients are shown. (E) The percentage of pTACI positive platelets in 37 HD and 70 breast cancer patients is shown. Within each box, horizontal lines denote 25^th percentile, median, 75^th percentile (bottom to top) of each group’s distribution values. Whiskers indicate maximal and minimal expression levels (p = 0.023).