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. 2021 Mar 17;11:634881. doi: 10.3389/fonc.2021.634881

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Copyright © 2021 Jin, Zhang, Zou, Li, Chen, Peng, Deng, Wen, Shen and Zhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular mechanisms underlying the anti-tumour effect of SHR-A1403. (A) Heatmap showing the upregulated and downregulated genes in cells treated with SHR-A1403 compared to control-treated cells. (B) Volcano plot showing the upregulated and downregulated genes in cells treated with SHR-A1403 compared to control-treated cells. (C,D) Pathway enrichment analysis showed that differentially expressed genes were enriched in pathways involved in migration, apoptosis, and cholesterol metabolism. (E) IPA showed that the cholesterol biosynthesis pathway was significantly inhibited by SHR-A1403. IPA, ingenuity pathway analysis.