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. 2021 Mar 17;11:634881. doi: 10.3389/fonc.2021.634881

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Copyright © 2021 Jin, Zhang, Zou, Li, Chen, Peng, Deng, Wen, Shen and Zhan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-tumour activity in vivo. (A,B) The subcutaneous tumour xenograft models established with the Aspc-1 cell line were treated with vehicle, 10 mg/kg SHR-A1403, or 10 mg/kg SHR-A1403 mAb. The tumour volume and tumour weight were measured on the indicated days. (C) Body weight changes in the subcutaneous models in five treatment groups. (D) Mouse subcutaneous tumour images obtained after dissection. The data are shown as the mean ± SEM. **P < 0.01, ***P < 0.001. mAb, monoclonal antibody.