Table 2.
Reason for discontinuation.
| Category | Total | |
|---|---|---|
| Discontinuations | n = 184,013 | |
| Reason for discontinuation—n (%) | Inadequate efficacy | 26,034 (14.1) |
| Disease progression/EDSS progression/EDSS 7+ | 4,218 (2.3) | |
| Tolerability | 15,491 (8.4) | |
| Adverse event/side effects/safety | 18,145 (9.9) | |
| Allergic reaction | 3,537 (1.9) | |
| Convenience | 8,428 (4.6) | |
| Pregnancy (planned or confirmed), contraception cessation | 6,733 (3.7) | |
| Scheduled stop | 12,147 (6.6) | |
| Non-adherence/non-compliance/no motivation | 4,555 (2.5) | |
| Development of neutralizing antibodies | 1,273 (0.7) | |
| Deceased | 266 (0.1) | |
| Secondary progressive MS | 1,109 (0.6) | |
| Other | 10,506 (5.7) | |
| Not reported/unknown | 76,887 (41.8) |
EDSS, Expanded disability status scale; MS, Multiple sclerosis.