Table 1.
Relationship between ZNF384 fusions and variables at diagnosis in adult Ph-negative BCP-ALL.
| Variable | All | ZNF384 fusions | P value | |
|---|---|---|---|---|
| Yes | No | |||
| Number of patients | 242 | 47 | 195 | |
| Age (y, median, range) | 32 (16–64) | 28 (16–62) | 33 (16–64) | 0.56 |
| Males (%) | 116 (47.9%) | 19 (40.4%) | 97 (49.7%) | 0.26 |
| WBC count (×109/L; median; range) | 8.1 (0.3–52.2) | 6.6 (1.6–225.0) | 8.2 (0.3–512.2) | 0.26 |
| Hemoglobin (g/L) | 87.0 (31.0–165.0) | 95.0 (40.0–132.0) | 84.0 (31.0–165.0) | 0.12 |
| Platelet count (×109/L; median; range) | 72.0 (0.6–510.0) | 161.0 (12.0–368.0) | 57.0 (0.6–510.0) | <0.0001 |
| IKZF1 deletion (%) (n = 138) | 25 (18.8%) | 3 (3/26, 11.5%) | 22 (22/112, 19.6%) | 0.41 |
| Complex karyotype (%) (n = 184) | 21 (11.4%) | 1 (1/37, 2.7%) | 20 (20/147, 13.6%) | 0.081 |
| High-risk (%) (n = 224) | 140 (62.5%) | 24 (24/45, 53.3%) | 116 (116/179, 64.8%) | 0.17 |