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. 2021 Mar 17;12:616055. doi: 10.3389/fphys.2021.616055

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Copyright © 2021 Kumar, Yang, Contreras, Garver, Bhattacharya, Fink, Rockwell and Watts.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bulk RNA-sequencing in MRPVAT of both sexes after 24 weeks on diet. Bulk RNA sequencing was performed on MRPVAT at 24 weeks on diet, from both sexes. Principal Component Analysis contained all the 20 samples (5 sample/diet/sex). (A) Venn diagram with the number of immune-related differentially expressed genes (DEGs) with respect to sex differences with HFD vs. CD (B) and the specific immune system processes affected (C). Venn diagram with the number of immune-related DEGs with respect to diet differences in males vs. females (D) and the specific immune system processes affected (E). G#: group number; M: male, F: female; C: CD; HF: HFD.

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