TABLE 4.
Recommended dosages and CFR values with a target value of fAUC24h/MIC ≥ 25.
| Population | Infectious fungal genera | |||
|---|---|---|---|---|
| Aspergillus spp. | Candida spp. | |||
| Dosage mg/kg | CFR % | Dosage mg/kg | CFR% | |
| Children aged 2–6 years | ||||
| NM | 12 | 80.1 | 6 | 80.2 |
| IM | 8 | 80.9 | 5 | 90.0 |
| PM | 5 | 86.0 | 3 | 91.9 |
| Children aged 6–12 years | ||||
| NM | 9 | 82.0 | 4 | 82.4 |
| IM | 6 | 84.9 | 3 | 82.0 |
| PM | 4 | 88.6 | 2 | 88.4 |
fAUC224h/MIC ≥ 25, ratio of free drug AUC during a 24-h period to minimum inhibitory concentration greater than or equal to 25; AUC, area under the concentration-time curve; NM, normal metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; CFR, cumulative fraction of response; all the recommended dosages are for the BID dosing regimens.