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. 2021 Mar 17;12:607719. doi: 10.3389/fgene.2021.607719

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Copyright © 2021 Xiao, Deng, Zeng, Sun, Yang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene set enrichment analysis (GO-base and KEGG-base). GSEA algorithm scored the enrichment of genes in the pathway in the ranked gene list. Enrichment score (ES) > 0 indicates that the distribution of the gene set is biased upstream of the ranking list, and ES < 0 shows the gene set distribution is biased downstream of the ranking list. (A,B), (a,b) represent the GO entries and KEGG signaling pathways with the lowest FDR values. (A) Brush border and (B) Metabolism of xenobiotics by cytochrome p450 are enriched in the male LRFI groups. (a) Cell fate commitment and (b) Basal cell carcinoma are enriched in LRFI groups in the female.