TABLE 3.

Gene set enrichment analysis (KEGG-base) in the male.

KEGG set	NES	FDR	Higher expression in HRFI or LRFI
Metabolism of xenobiotics by cytochrome p450	–2.40002	5.02E-06	LRFI
Fatty acid metabolism	–2.15454	6.10E-04	LRFI
Drug metabolism cytochrome p450	–2.13537	4.07E-04	LRFI
Peroxisome	–2.00773	0.002549	LRFI
PPAR signaling pathway	–1.93454	0.0089	LRFI
Glutathione metabolism	–1.86585	0.016234	LRFI
Oxidative phosphorylation	–1.86476	0.014085	LRFI
Pyruvate metabolism	–1.85897	0.012981	LRFI
Retinol metabolism	–1.84681	0.01302	LRFI
Drug metabolism other enzymes	–1.79034	0.021592	LRFI
Focal adhesion	1.906565	0.033723	HRFI
ECM receptor interaction	1.828651	0.036793	HRFI

NES, enrichment score; FDR, false discovery rate of the p-value.